HFE Mutations C282Y and H63D in Iranian Population With Type 2 Diabetes
نویسندگان
چکیده
منابع مشابه
hfe mutations c282y and h63d in iranian population with type 2 diabetes
conclusions our study showed a significant association between h63d and c282y mutations and the risk of type 2 diabetes in iranian population. background type 2 diabetes (t2d) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. objectives regarding the relationship between type 2...
متن کاملRole of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy.
OBJECTIVE In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associated with an increased risk for diabetes. There are also some reports that suggest that iron overload might cause diabetic nephropathy. RESEARCH DESIGN AND METHODS We performed an association study to assess the role...
متن کاملFrequency of Two Common HFE Gene Mutations (C282Y and H63D) in a Group of Iranian Patients With Cryptogenic Cirrhosis
BACKGROUND The human HFE gene (a key component of iron homeostasis in humans) is involved in hereditary hemochromatosis, a common autosomal recessive genetic disorder that is characterized by excessive intestinal iron absorption and progressive iron overload. OBJECTIVES In this study, we assessed the frequency of two common forms of hemochromatosis HFE gene mutation (C282Y and H63D) in patien...
متن کاملAssociation of HFE mutations (C282Y and H63D) with iron overload in blood donors from Mexico City.
BACKGROUND AND OBJECTIVE Iron overload has been associated with HFE mutations (C282Y and H63D). We investigated the association between these mutations and high serum ferritin in a sample of healthy adult men. DESIGN AND METHODS We enrolled unrelated blood donors from three hospitals in Mexico City in a crosssectional study. Serum ferritin (SF) was determined to define iron overload, and HFE ...
متن کاملAuthor’s Reply: HFE Gene Mutations (C282Y and H63D) in a Group of Patients With Cryptogenic Cirrhosis
I would like to thank Dr Sendi and Mohseni for their interest in our study.In this letter the authors have summarized the contributory effects of hereditary hemochromatosis (HH) in liver diseases in different populations (1). I completely agree with them concerning the underlying causes of cryptogenic cirrhosis which in countries such as Iran is most commonly nonalcoholic steatohepatitis (NASH)...
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ژورنال
عنوان ژورنال: Jentashapir Journal of Health Research
سال: 2015
ISSN: 2345-4067
DOI: 10.5812/jjhr.24659